Collagen Stimulating Fillers And How They Differ From The Others

Here at Halycon Skin I use two leading brands of collagen stimulating fillers. Regulations keep me from mentioning the brand names but I’d like to talk about the active ingredients and how they work to give a longer lasting very natural look with the added benefit of improvement in the overlying skin.

Many of you are familiar with hyaluronic acid subdermal fillers. They act like sugar pillows plumping the skin and filling age-related deficits. They are metabolised over time and last 6-18 months. If you don’t like the look or there is a complication, they are dissolvable with an enzyme called hyaluronidase.

A new breed of fillers includes the collagen simulating agents. They act to treat wrinkles and replace volume but do so by stimulating the fibroblasts in the skin to make more collagen. This gives a natural result. They are useful for facial and hand rejuvenation. In the past they have been used to treat the fat wasting and facial hollowing caused by a condition called lipoatrophy experienced by patients with HIV who were taking medications called protease inhibitors.

Calcium Hydroxylapatite (CaHA)

Ca HA is a biocompatible, biodegradable, resorbable and biostimulatory filler that comes in microspheres suspended in a vehicle of sodium carboxymethylcellulose (CMC), water and glycerin. The CMC allows for an immediate result but the real action occurs over the following 6-12 weeks, whereby the CMC is metabolised and disappears and the CaHA takes over to stimulate the production of collagen under the skin. The CaHA is broken down over time, so it is not a permanent filler. The collagen stimulatory action lasts around 12 months and gives a great natural result.

Polycaprolactone (PCL) based fillers

PCL fillers contain 30% PCL and 70% CMC (see previous) It works in a similar way to CaHA by using small microspheres to stimulate collagen production. These microspheres break down over 1,2,3 or 4 years depending which product is chosen.

The collagen stimulating fillers are not reversible with hyaluronidase. It is therefore important to ensure the injector is experienced with proper qualifications and the capacity to independently manage complications. It is better to be under-corrected and have a review at 3 months as this is the time frame required to see the full effect of the product. These products should not be used in the tear trough or the lips. I enjoy using the collagen stimulators or “biostimulators” as they are sometimes known as they give a natural result and often result in an improvement in the quality of overlying skin.

If you need any further information, would like a consultation with me or to make a booking, get in contact by clicking here.


Dr Lizzy Gascoigne
Halcyon Skin